Homeopathic Treatment for Crigler Najjar Syndrome

What is Crigler Najjar Syndrome?

Understanding Crigler-Najjar Syndrome

If your near and dear ones are suffering from some genetic disease like Crigler Najjar syndrome, don’t be disheartened. Homeopathic treatment for Crigler-Najjar syndrome offers effective management, reducing the impact of gene mutations for a better quality of life.

Crigler Najar Syndrome

A Battle Against Bilirubin Buildup

Crigler-Najjar syndrome (CNS) is a rare genetic disorder. It is caused by a mutation of the UGT1A1 gene. It is an autosomal recessive disease. Hence it is commonly seen in a consanguineous marriage.  Crigler Najjar syndrome affects the metabolism of bilirubin, hence causing an increase in levels of unconjugated bilirubin. 

What is Bilirubin?

Bilirubin is a yellow pigment, formed due to the breakdown of RBC. This unconjugated bilirubin (indirect bilirubin) is converted into conjugated bilirubin by the Liver. The Conjugated bilirubin is water soluble and can be easily excreted in the bile. 

In Crigler-Najjar syndrome, since the unconjugated bilirubin is not metabolized, the levels of bilirubin increase. These high levels of bilirubin cause damage to infants' brains.

Signs and Symptoms of Crigler Najjar Syndrome

The main symptom of Crigler-Najjar syndrome is jaundice. In jaundice, there is yellowing of the skin and eyes. In severe instances, elevated bilirubin levels can impact brain development and function, leading to:

  • Drowsiness
  • Lethargy
  • Irritability
  • Poor feeding
  • Seizures
  • Developmental delays

Types of Crigler Najar Syndrome

There are 2 types of Crigler-Najjar syndrome depending on the severity of enzyme deficiency:

  • Type I (severe): This form marks the most critical manifestation, characterized by a nearly complete absence of the enzyme essential for bilirubin processing. Newborns with Type I CNS showcase persistent yellowing of the skin and eyes (jaundice), posing life-threatening risks if left unaddressed.

  • Type II (mild): In this type, bilirubin levels are lower, and symptoms tend to be less pronounced. Jaundice may be milder and could even improve with time.

Differential Diagnosis

There are 5 types of genetic diseases related to problems in Bilirubin Metabolism.

(Genetic cause of Abnormal bilirubin metabolism

  1. Crigler Najjar Syndrome
  2. Arias syndrome
  3. Gilbert's syndrome
  4. Dubin–Johnson syndrome
  5. Rotor syndrome


Causes of Crigler Najjar Syndrome

Crigler Najjar Syndrome is autosomal recessive genetic pattern. This indicates that for a child to develop the condition, they must inherit two mutated genes, one from each parent. Parents carrying a single mutated gene are carriers and typically remain asymptomatic. Or there can be a de novo mutations in the gene.


Diagnosis & Treatment For Crigler Najjar Syndrome

The following are the tests recommended to diagnose Crigler Najjar Syndrome.

  1. CBC
  2. Liver function test
  3. MRI brain to assess the brain damage
  4. Gene testing of the child
  5. Gene testing of both parents. (If only one copy of gene mutation is seen then it is known as Gilbert syndrome)

Conventional Treatment For Crigler Najjar Syndrome

The following treatments are recommended.

  • Phototherapy: Utilizing specialized lights to aid bilirubin breakdown.
  • Phenobarbital: Administering medication to enhance bilirubin excretion.
  • Plasma exchange: Conducting a procedure to remove bilirubin-rich blood plasma, substituting it with healthy plasma.
  • Liver transplant: In severe scenarios, a liver transplant might be necessary to provide a functional liver with normal bilirubin processing capabilities

HomoeoCARE's Approach

In all genetic diseases, we have a specialized approach based on the research of Dr. Pravin Jain. First, we try to check the genetic reports of both the parents and the child. If the parent's reports are negative, then it seems that is a case of de novo mutation. This this scenario, we take the mother's history during pregnancy to find out the cause of the mutation.

If both the parent's geentic tests are posotive for the mutation, then we also take adidtional symptoms from the parent's history and wholistically analyse all the data.

This approach has helped HomoeoCARE to give better results in genetic diseases. With homeopathy, we can minimize the impact of genes on the brain and can some extent reverse the brain damage. One such case of Crigler Najjar syndrome came to HomoeoCARE and our team successfully handled him

HomoeoCARE's Success

A male child, aged 1 month and 22 days, was diagnosed with Crigler Najjar Syndrome. At birth, his bilirubin levels were very high (17.8). Initially, the doctors thought it to be physiological jaundice and he received phototherapy and was admitted in the NICU for nine days. However, his bilirubin levels did not become normal. His bilirubin levels kept increasing, and the doctors diagnosed as Crigler Najjar Syndrome. Conventional treatments failed to improve his condition, so the parents opted for homeopathic treatment at HomoeoCARE.

After starting the homeopathic treatment, within 2 weeks the child's bilirubin levels dropped from 26 to 17. It further improved from 7.01 and 4.8, and finally in six months returned to normal. The child’s general health also improved significantly. As his general condition improved, his developmental milestones were also improved. Now he is involved in activities typical for his age, such as riding a bicycle. This case highlights the effectiveness of homeopathic treatment for genetic conditions like Crigler Najjar Syndrome. The child's developmental progress shows no deficiency, indicating a complete return to normal activities and milestones


Chat with a doctor privately

If you have any queries regarding your disease or any symptoms, Click here to send a WhatsApp message. Our doctors will be happy to answers these.

Chat with a doctor privately

If you have any queries regarding your disease or any symptoms, Click here to send a WhatsApp message. Our doctors will be happy to answers these.

Book an Appointment

If you want to visit our clinic, Click here to book an appointment.

Online treatment

If you are a busy professional, or you are living in a remote town or city, with no best homeopathic doctor near you, Click here to start an online homeopathic treatment with the world's exclusive and only specialized pediatric homeopathic clinic, managed by Dr. Pravin Jain world-renowned homeopathic pediatric expert.

Copyright ©2021 Homoeocare